Association of Sleep Duration With Atrial Fibrillation and Heart Failure: A Mendelian Randomization Analysis.

ABSTRACT: Both short (<7 h per night) and long (≥9 h per night) sleep durations are related to atrial fibrillation (AF) and heart failure (HF), but their causality has not been confirmed. We applied Mendelian randomization (MR) approaches to estimate the causal association between genetically determined sleep duration and the risk of AF and HF. We performed two-sample MR analysis to obtain the effect of sleep duration on AF and HF. Instrumental variables were constructed using genetic variants known to be associated with continuous sleep duration, short sleep duration, and long sleep duration. MR estimates of the effect of sleep duration on AF and HF were derived based on two large meta-analyses of genome-wide association studies. The pooled MR estimate demonstrated a significant protective effect o

SUBMITTER: Zhao J 

PROVIDER: S-EPMC7943616 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature