HvRNASET2 Regulate Connective Tissue and Collagen I Remodeling During Wound Healing Process.

ABSTRACT: Several studies have recently demonstrated that the correct regeneration of damaged tissues and the maintaining of homeostasis after wounds or injuries are tightly connected to different biological events, involving immune response, fibroplasia, and angiogenetic processes, in both vertebrates and invertebrates. In this context, our previous data demonstrated that the Hirudo verbana recombinant protein rHvRNASET2 not only plays a pivotal role in innate immune modulation, but is also able to activate resident fibroblasts leading to new collagen production, both in vivo and in vitro. Indeed, when injected in the leech body wall, which represents a consolidated invertebrate model for studying both immune response and tissue regeneration, HvRNASET2 induces mac

SUBMITTER: Baranzini N 

PROVIDER: S-EPMC7943632 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature