A low cartilage formation and repair endotype predicts radiographic progression of symptomatic knee osteoarthritis.

ABSTRACT:

Background

Osteoarthritis (OA) is a disease with multiple endotypes. A hallmark of OA is loss of cartilage; however, it is evident that the rate of cartilage loss differs among patients, which may partly be attributed to differential capacity for cartilage repair. We hypothesize that a low cartilage repair endotype exists and that such endotypes are more likely to progress radiographically. The aim of this study is to examine the associations of level of cartilage formation with OA severity and radiographic OA progression. We used the blood-based marker PRO-C2, reflecting type II collagen formation, to assess levels of cartilage formation.

Materials and methods

The type II collagen propeptide PRO-C2 was measured in the serum/plasma of knee OA subjects from New York Universit

SUBMITTER: Luo Y 

PROVIDER: S-EPMC7943687 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature