Proteasome-Generated <i>cis</i>-Spliced Peptides and Their Potential Role in CD8⁺ T Cell Tolerance.

ABSTRACT: The human immune system relies on the capability of CD8⁺ T cells to patrol body cells, spot infected cells and eliminate them. This cytotoxic response is supposed to be limited to infected cells to avoid killing of healthy cells. To enable this, CD8⁺ T cells have T Cell Receptors (TCRs) which should discriminate between self and non-self through the recognition of antigenic peptides bound to Human Leukocyte Antigen class I (HLA-I) complexes-i.e., HLA-I immunopeptidomes-of patrolled cells. The majority of these antigenic peptides are produced by proteasomes through either peptide hydrolysis or peptide splicing. Proteasome-generated cis-spliced peptides derive from a given antigen, are immunogenic and frequently presented by HLA-I complexes. Theoretically, they a

SUBMITTER: Mansurkhodzhaev A 

PROVIDER: S-EPMC7943738 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature