Task-generic and task-specific connectivity modulations in the ADHD brain: an integrated analysis across multiple tasks.

ABSTRACT: Attention-deficit/hyperactivity disorder (ADHD) is associated with altered functioning in multiple cognitive domains and neural networks. This paper offers an overarching biological perspective across these. We applied a novel strategy that extracts functional connectivity modulations in the brain across one (P_single), two (P_mix) or three (P_all) cognitive tasks and compared the pattern of modulations between participants with ADHD (n-89), unaffected siblings (n = 93) and controls (n = 84; total N = 266; age range = 8-27 years). Participants with ADHD had significantly fewer P_all connections (modulated regardless of task), but significantly more task-specific (P_single) connectivity modulations than the other groups. The amplitude of the

SUBMITTER: Chauvin RJ 

PROVIDER: S-EPMC7943764 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature