Ex vivo characterization of Breg cells in patients with chronic Chagas disease.

ABSTRACT: Despite the growing importance of the regulatory function of B cells in many infectious diseases, their immunosuppressive role remains elusive in chronic Chagas disease (CCD). Here, we studied the proportion of different B cell subsets and their capacity to secrete IL-10 ex vivo in peripheral blood from patients with or without CCD cardiomyopathy. First, we immunophenotyped peripheral blood mononuclear cells from patients according to the expression of markers CD19, CD24, CD38 and CD27 and we showed an expansion of total B cell and transitional CD24^highCD38^high B cell subsets in CCD patients with cardiac involvement compared to non-infected donors. Although no differences were observed in the frequency of total IL-10 producing B cells (B10) among the groups, CCD patie

SUBMITTER: Girard MC 

PROVIDER: S-EPMC7943772 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature