Implication of TIGIT⁺ human memory B cells in immune regulation.

ABSTRACT: Regulatory B cells (Bregs) contribute to immune regulation. However, the mechanisms of action of Bregs remain elusive. Here, we report that T cell immunoreceptor with Ig and ITIM domains (TIGIT) expressed on human memory B cells especially CD19⁺CD24^hiCD27⁺CD39^hiIgD^-IgM⁺CD1c⁺ B cells is essential for effective immune regulation. Mechanistically, TIGIT on memory B cells controls immune response by directly acting on T cells and by arresting proinflammatory function of dendritic cells, resulting in the suppression of Th1, Th2, Th17, and CXCR5⁺ICOS⁺ T cell response while promoting immune regulatory function of T cells. TIGIT⁺ memory B cells are also superior to other B cells at express

SUBMITTER: Hasan MM 

PROVIDER: S-EPMC7943800 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature