AHR Regulates NK Cell Migration via ASB2-Mediated Ubiquitination of Filamin A.

ABSTRACT: Natural killer (NK) cells are effector cells of the innate immune system involved in defense against virus-infected and transformed cells. The effector function of NK cells is linked to their ability to migrate to sites of inflammation or damage. Therefore, understanding the factors regulating NK cell migration is of substantial interest. Here, we show that in the absence of aryl hydrocarbon receptor (AHR), a ligand-activated transcription factor, NK cells have reduced capacity to migrate and infiltrate tumors in vivo. Analysis of differentially expressed genes revealed that ankyrin repeat and SOCS Box containing 2 (Asb2) expression was dramatically decreased in Ahr^-/- NK cells and that AhR ligands modulated its expression. Further, AhR directly regulated th

SUBMITTER: Shin JH 

PROVIDER: S-EPMC7943850 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature