Landscape and dynamics of single tumor and immune cells in early and advanced-stage lung adenocarcinoma.

ABSTRACT:

Background

Lung adenocarcinoma (LUAD) patients with different American Joint Committee on Cancer stages have different overall 5-year survival rates. The tumor microenvironment (TME) and intra-tumor heterogeneity (ITH) have been shown to play a crucial role in the occurrence and development of tumors. However, the TME and ITH in different lesions of LUAD have not been extensively explored.

Methods

We present a 204,157-cell catalog of the TME transcriptome in 29 lung samples to systematically explore the TME and ITH in the different stages of LUAD. Traditional RNA sequencing data and complete clinical information were downloaded from publicly available databases.

Results

Based on these high-quality cells, we constructed a single-cell network underlying cellular and mol

SUBMITTER: Chen Z 

PROVIDER: S-EPMC7943914 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature