Implementation of in silico methods to predict common epitopes for vaccine development against Chikungunya and Mayaro viruses.

ABSTRACT: Being a Positive sense RNA virus the recent reemergence of Chikungunya and Mayaro virus has taken the concern of the leading scientific communities of the world. Though the outbreak of Mayaro virus is limited to Neotropical region only, Chikungunya is already identified in over 60 countries around the world. Besides, the lack of a strong protective treatment, misdiagnosis issue and co-circulation of both the viruses calls for a new strategy which could potentially prevent these infections from spreading. In this study, we therefore, identified the peptide based vaccine candidates e.g. epitopes for B cell and T cell from Chikungunya virus which also showed to be homologous to the Mayaro virus through immuno-informatics and computational approaches. Final epitopes identified from the most an

SUBMITTER: Hoque H 

PROVIDER: S-EPMC7944042 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature