Epidemiological and evolutionary consequences of periodicity in treatment coverage.

ABSTRACT: Host heterogeneity is a key driver of host-pathogen dynamics. In particular, the use of treatments against infectious diseases creates variation in quality among hosts, which can have both epidemiological and evolutionary consequences. We present a general theoretical model to highlight the consequences of different imperfect treatments on pathogen prevalence and evolution. These treatments differ in their action on host and pathogen traits. In contrast with previous studies, we assume that treatment coverage can vary in time, as in seasonal or pulsed treatment strategies. We show that periodic treatment strategies can limit both disease spread and virulence evolution, depending on the type of treatment. We also introduce a new method to analytically calculate the selection gradient in per

SUBMITTER: Walter A 

PROVIDER: S-EPMC7944112 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature