The effect of complicated febrile convulsion on hippocampal function and its antiepileptic treatment significance.

ABSTRACT:

Background

This study aimed to explore the effects of complex febrile seizures on hippocampal function and the significance of antiepileptic therapy.

Methods

A total of 150 children with complex febrile seizures admitted to our hospital from July 2017 to July 2020 were included in the study. The VPA group was given sodium valproate treatment; the LEV group was given levetiracetam treatment; and the observation group was given basic treatment. The efficacy of the patients was evaluated after medication. A complex febrile seizure young mouse model was constructed, and the hippocampal cell morphology and BCL-2 expression of the mice pups were analyzed. A Morris water maze was used to detect the changes in cognitive function of the young mice with complex febrile seizures.

Re

SUBMITTER: Li B 

PROVIDER: S-EPMC7944171 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature