Can domperidone decrease transit time of pediatric video capsule endoscopy? A randomized controlled trial.

ABSTRACT:

Background

The complete examination rate of video capsule endoscopy can be increased by reduced gastric transit time (GTT) and or small bowel transit time (SBTT). This study aims to examine whether the prokinetic domperidone reduces GTT and/or SBTT in pediatric patients undergoing video capsule endoscopy (VCE).

Methods

We performed a single-center randomized controlled trial (n=200) to evaluate the effect of domperidone on GTT and SBTT among pediatric patients in a tertiary university-affiliated hospital for children. We explored whether patients randomized to domperidone had increased GTT, SBTT (primary outcomes) or higher complete examination rate (secondary outcome). The safety outcomes were the adverse effects in the domperidone group. This study was registered on Clinic

SUBMITTER: Wu J 

PROVIDER: S-EPMC7944175 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature