Web-based calculator for biliary atresia screening in neonates and infants with cholestasis.

ABSTRACT:

Background

Distinguishing biliary atresia from non-biliary atresia in patients with cholestasis is challenging, as these conditions have a similar clinical presentation. We developed and externally validated a screening model for biliary atresia and devised a web-based calculator for use in clinical settings.

Methods

A screening model was developed based on data from 227 cholestatic infants (82 and 145 with and without biliary atresia, respectively) and validated in 234 infants (90 and 144 with and without biliary atresia, respectively) admitted to three hospitals. Variables were selected from routine examination results using the least absolute shrinkage and selection operator method and entered into a logistic regression model to construct a biliary-atresia-risk-predicting

SUBMITTER: Zhao D 

PROVIDER: S-EPMC7944186 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature