The influence of pregnancy-induced hypertension syndrome on the metabolism of newborns.

ABSTRACT:

Background

Pregnancy-induced hypertension (PIH) is associated with an increased number of neonatal complications, but its impact on neonatal metabolism remains unclear. This study aimed to investigate the differential metabolomics of infants born to mothers with and without PIH.

Methods

Blood samples of a total of 115 infants born to mothers with (n=56) and without (n=59) PIH were collected and assigned to two groups, respectively, from the neonatal department of Sixth Affiliated Hospital of Sun Yat-Sen University. A tandem mass spectrometer was used to generate metabolic profiling of amino acid, free carnitine, and acyl-carnitines. The resulting data were analyzed using orthogonal partial least squares discriminant analysis based on the difference between infants born to mo

SUBMITTER: Hao H 

PROVIDER: S-EPMC7944188 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature