Role of thoracic radiotherapy in extensive stage small cell lung cancer: a systemic review and meta-analysis.

ABSTRACT:

Background

The role of thoracic consolidation radiotherapy in patients with extensive stage small cell lung cancer (ES-SCLC) remains controversial. This study aimed to evaluate the efficacy of thoracic radiotherapy (TRT) in these patients.

Methods

A systematic literature search was performed in PubMed, Embase, and the Cochrane library to identify qualified clinical studies. The hazard ratios (HRs) and 95% confidence intervals (CIs) of overall survival (OS), progression-free survival (PFS) and local recurrence-free survival (LRFS) were extracted, and toxicity of the TRT group versus non-TRT group was analyzed.

Results

A total of 12 studies were included in this meta-analysis, including 936 patients in the TRT group and 1,059 patients in the non-TRT group. The combined

SUBMITTER: Li AM 

PROVIDER: S-EPMC7944300 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature