Effects of earthworm extract on the lipid profile and fatty liver induced by a high-fat diet in guinea pigs.

ABSTRACT:

Background

Non-alcoholic fatty liver disease (NAFLD), characterized by the accumulation of excess fat in the liver in people who consume little or no alcohol, is becoming increasingly common around the world, especially in developed countries. Extracts from earthworms have been used as alternative therapies for a variety of diseases but not in NAFLD. Therefore, the aim of this study was to investigate the effect of earthworm extract (EE) on diet-induced fatty liver disease in guinea pigs.

Methods

EE was extracted, and the effect of EE on the lipid levels and liver damage in guinea pigs fed a high-fat diet (HFD) was assessed. Thirty male guinea pigs at 3 weeks of age were allocated equally to five groups, namely, chow diet, HFD, and HFD with different dosages (0.3, 1.4 and 6.

SUBMITTER: Deng Z 

PROVIDER: S-EPMC7944315 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature