Identification of drug compounds for keloids and hypertrophic scars: drug discovery based on text mining and DeepPurpose.

ABSTRACT:

Background

Keloids (KL) and hypertrophic scars (HS) are forms of abnormal cutaneous scarring characterized by excessive deposition of extracellular matrix and fibroblast proliferation. Currently, the efficacy of drug therapies for KL and HS is limited. The present study aimed to investigate new drug therapies for KL and HS by using computational methods.

Methods

Text mining and GeneCodis were used to mine genes closely related to KL and HS. Protein-protein interaction analysis was performed using Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) and Cytoscape. The selection of drugs targeting the genes closely related to KL and HS was carried out using Pharmaprojects. Drug-target interaction prediction was performed using DeepPurpose, through which candida

SUBMITTER: Pan Y 

PROVIDER: S-EPMC7944324 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature