Evaluation of Selective Survival and Sex/Gender Differences in Dementia Incidence Using a Simulation Model.

ABSTRACT:

Importance

Dementia research is susceptible to bias arising from selective survival, a process that results in individuals with certain characteristics disproportionately surviving to old age. Spurious associations between risk factors and dementia may be induced when factors associated with longer survival also influence dementia incidence.

Objective

To assess the role of selective survival in explaining reported sex/gender differences in dementia incidence.

Design, setting, and participants

This decision analytical model used a simulated cohort of US participants aged 50 years and without dementia at baseline followed up for incident dementia through age 95 years. Selective survival was induced by a selection characteristic (eg, childhood social disadvantage or Alzh

SUBMITTER: Shaw C 

PROVIDER: S-EPMC7944377 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature