Fatty acid amide hydrolase is lower in young cannabis users.

ABSTRACT: We have recently shown that levels of fatty acid amide hydrolase (FAAH), the enzyme that metabolizes the endocannabinoid anandamide, are lower in the brains of adult cannabis users (CUs) (34 ± 11 years of age), tested during early abstinence. Here, we examine replication of the lower FAAH levels in a separate, younger cohort (23 ± 5 years of age). Eighteen healthy volunteers (HVs) and fourteen CUs underwent a positron emission tomography scan using the FAAH radioligand [¹¹ C]CURB. Regional [¹¹ C]CURB binding was calculated using an irreversible two-tissue compartment model with a metabolite-corrected arterial plasma input function. The FAAH C385A genetic polymorphism (rs324420) was included as a covariate. All CUs underwent a urine screen to confirm recent cannabis us

SUBMITTER: Jacobson MR 

PROVIDER: S-EPMC7944390 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature