Viability testing of discarded livers with normothermic machine perfusion: Alleviating the organ shortage outweighs the cost.

ABSTRACT:

Background

Over 700 donor livers are discarded annually in the United States due to high risk of poor graft function. The objective of this study was to determine the impact of using normothermic machine perfusion to identify transplantable livers among those currently discarded.

Study design

A series of 21 discarded human livers underwent viability assessment during normothermic machine perfusion. Cross-sectional analysis of the Scientific Registry of Transplant Recipients database and cost analysis was performed to extrapolate the case series to national experience.

Results

21 discarded human livers were included in the perfusion cohort. 11 of 20 (55%) eligible grafts met viability criteria for transplantation. Grafts in the perfusion cohort had a similar donor risk

SUBMITTER: Raigani S 

PROVIDER: S-EPMC7944462 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature