Development and Characterization of a Probe Device toward Intracranial Spectroscopy of Traumatic Brain Injury.

ABSTRACT: Traumatic brain injury is a leading cause of mortality worldwide, often affecting individuals at their most economically active yet no primary disease-modifying interventions exist for their treatment. Real-time direct spectroscopic examination of the brain tissue within the context of traumatic brain injury has the potential to improve the understanding of injury heterogeneity and subtypes, better target management strategies and organ penetrance of pharmacological agents, identify novel targets for intervention, and allow a clearer understanding of fundamental biochemistry evolution. Here, a novel device is designed and engineered, delivering Raman spectroscopy-based measurements from the brain through clinically established cranial access techniques. Device prototyping is undertaken wit

SUBMITTER: Mowbray M 

PROVIDER: S-EPMC7944476 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature