Maternal HIV, antiretroviral timing, and spontaneous preterm birth in an urban Zambian cohort: the role of local and systemic inflammation.

ABSTRACT:

Objective

To assess plasma and vaginal inflammation in three antenatal groups (HIV-uninfected women, HIV-infected women entering care on preconceptional ART, and HIV-infected women not on preconceptional ART) and whether these measures are associated with spontaneous preterm birth (sPTB).

Design

Case--control study nested within a pregnancy cohort in Lusaka, Zambia.

Methods

We analyzed 11 pro-inflammatory and two anti-inflammatory markers in 207 women with paired plasma and vaginal specimens collected between 16 and 20 gestational weeks. Among 51 HIV-infected women, we repeated the assays in 24-34-week samples. We used confirmatory factor analysis to create inflammation scores and compared them among the three groups.

Results

At baseline, HIV-infected women not

SUBMITTER: Rittenhouse KJ 

PROVIDER: S-EPMC7944942 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature