Vitamin D deficiency increases severity of paclitaxel-induced peripheral neuropathy.

ABSTRACT:

Purpose

Approximately 25% of patients receiving weekly paclitaxel for breast cancer require treatment disruptions to avoid severe, irreversible peripheral neuropathy (PN). Vitamin insufficiencies are PN risk factors in many diseases, but their relevance to chemotherapy-induced PN is unknown.

Methods

We investigated whether baseline insufficiency of vitamin D, vitamin B12, folate, or homocysteine increased PN in patients with breast cancer receiving weekly paclitaxel in a retrospective analysis of a prospective observational study. Patient-reported PN was collected at baseline and during treatment on the Quality of Life Questionnaire Chemotherapy-Induced Peripheral Neuropathy (CIPN20). The primary analysis tested associations between vitamin deficiency and the maximum increas

SUBMITTER: Jennaro TS 

PROVIDER: S-EPMC7945004 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature