Dataset Information

Protein storytelling through physics.

ABSTRACT: Every protein has a story-how it folds, what it binds, its biological actions, and how it misbehaves in aging or disease. Stories are often inferred from a protein's shape (i.e., its structure). But increasingly, stories are told using computational molecular physics (CMP). CMP is rooted in the principled physics of driving forces and reveals granular detail of conformational populations in space and time. Recent advances are accessing longer time scales, larger actions, and blind testing, enabling more of biology's stories to be told in the language of atomistic physics.

SUBMITTER: Brini E

PROVIDER: S-EPMC7945008 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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Publications

Protein storytelling through physics.

Brini Emiliano E Simmerling Carlos C Dill Ken K

Science (New York, N.Y.) 20201101 6520

Every protein has a story-how it folds, what it binds, its biological actions, and how it misbehaves in aging or disease. Stories are often inferred from a protein's shape (i.e., its structure). But increasingly, stories are told using computational molecular physics (CMP). CMP is rooted in the principled physics of driving forces and reveals granular detail of conformational populations in space and time. Recent advances are accessing longer time scales, larger actions, and blind testing, enabl ...[more]

PMID: 33243857

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Dataset Information

Protein storytelling through physics.

Publications

Protein storytelling through physics.

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