The Functional Foundations of Episodic Memory Remain Stable Throughout the Lifespan.

ABSTRACT: It has been suggested that specific forms of cognition in older age rely largely on late-life specific mechanisms. Here instead, we tested using task-fMRI (n = 540, age 6-82 years) whether the functional foundations of successful episodic memory encoding adhere to a principle of lifespan continuity, shaped by developmental, structural, and evolutionary influences. We clustered regions of the cerebral cortex according to the shape of the lifespan trajectory of memory activity in each region so that regions showing the same pattern were clustered together. The results revealed that lifespan trajectories of memory encoding function showed a continuity through life but no evidence of age-specific mechanisms such as compensatory patterns. Encoding activity was related to general cognitive abili

SUBMITTER: Vidal-Pineiro D 

PROVIDER: S-EPMC7945016 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature