Temporal Dynamics of Functional Brain States Underlie Cognitive Performance.

ABSTRACT: The functional organization of the human brain adapts dynamically in response to a rapidly changing environment. However, the relation of these rapid changes in functional organization to cognitive functioning is not well understood. This study used a graph-based time-frame modularity analysis approach to identify temporally recurrent functional configuration patterns in neural responses to an n-back working memory task during fMRI. Working memory load was manipulated to investigate the functional relevance of the identified brain states. Four distinct brain states were defined by the predominant patterns of activation in the task-positive, default-mode, sensorimotor, and visual networks. Associated with escalating working memory load, the occurrence of the task-positive state and the prob

SUBMITTER: Gu H 

PROVIDER: S-EPMC7945029 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature