A new rapid diagnostic system with ambient mass spectrometry and machine learning for colorectal liver metastasis.

ABSTRACT:

Background

Probe electrospray ionization-mass spectrometry (PESI-MS) can rapidly visualize mass spectra of small, surgically obtained tissue samples, and is a promising novel diagnostic tool when combined with machine learning which discriminates malignant spectrum patterns from others. The present study was performed to evaluate the utility of this device for rapid diagnosis of colorectal liver metastasis (CRLM).

Methods

A prospectively planned study using retrospectively obtained tissues was performed. In total, 103 CRLM samples and 80 non-cancer liver tissues cut from surgically extracted specimens were analyzed using PESI-MS. Mass spectra obtained by PESI-MS were classified into cancer or non-cancer groups by using logistic regression, a kind of machine learning. Next, t

SUBMITTER: Kiritani S 

PROVIDER: S-EPMC7945316 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature