Ontology highlight
ABSTRACT:
SUBMITTER: Tian X
PROVIDER: S-EPMC7946002 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Tian Xiangge X Zhou Meirong M Ning Jing J Deng Xiaopeng X Feng Lei L Huang Huilian H Yao Dahong D Ma Xiaochi X
Journal of enzyme inhibition and medicinal chemistry 20211201 1
Human Cytochrome P450 2J2 (CYP2J2) as an important metabolic enzyme, plays a crucial role in metabolism of polyunsaturated fatty acids (PUFAs). Elevated levels of CYP2J2 have been associated with various types of cancer, and therefore it serves as a potential drug target. Herein, using a high-throughput screening approach based on enzymic activity of CYP2J2, we rapidly and effectively identified a novel natural inhibitor (Piperine, <b>9a</b>) with IC<sub>50</sub> value of 0.44 μM from 108 common ...[more]