Mucin degrader Akkermansia muciniphila accelerates intestinal stem cell-mediated epithelial development.

ABSTRACT: Mucin-degrading bacteria are densely populated in the intestinal epithelium; however, their interaction with intestinal stem cells (ISCs) and their progeny have not been elucidated. To determine whether mucin-degrading bacteria play a role in gut homeostasis, mice were treated with Akkermansia muciniphila, a specialized species that degrades mucin. Administration of A. muciniphila for 4 weeks accelerated the proliferation of Lgr5⁺ ISCs and promoted the differentiation of Paneth cells and goblet cells in the small intestine (SI). We found similar effects of A. muciniphila in the colon. The levels of acetic and propionic acids were higher in the cecal contents of A. muciniphila-treated mice than in PBS-treated mice. SI organoids treated with cecal conte

SUBMITTER: Kim S 

PROVIDER: S-EPMC7946046 | biostudies-literature | 2021 Jan-Dec

REPOSITORIES: biostudies-literature