Medroxyprogesterone opposes estradiol-induced renal damage in midlife ovariectomized Long Evans rats.

ABSTRACT:

Objective

Our laboratory previously published that long-term administration of estradiol (E2) was detrimental to the kidneys of midlife ovariectomized Long Evans rats, contrasting clinical studies in showing that menopausal hormone therapy is associated with decreased albuminuria. However, it is unknown whether this renal benefit was due to estrogen and/or the combination with progestogen. Therefore, the objective of the current study was to determine the impact of medroxyprogesterone (MPA) on E2-mediated renal damage using a rodent model.

Methods

Female Long Evans retired breeders underwent ovariectomy at 11 months of age and were treated for 40 days with subcutaneous E2, E2+MPA or vehicle at doses mimicking that of menopausal hormone therapy (N = 5-7 per group). Systolic b

SUBMITTER: Zimmerman MA 

PROVIDER: S-EPMC7946153 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature