Exposing distinct subcortical components of the auditory brainstem response evoked by continuous naturalistic speech.

ABSTRACT: Speech processing is built upon encoding by the auditory nerve and brainstem, yet we know very little about how these processes unfold in specific subcortical structures. These structures are deep and respond quickly, making them difficult to study during ongoing speech. Recent techniques have begun to address this problem, but yield temporally broad responses with consequently ambiguous neural origins. Here, we describe a method that pairs re-synthesized 'peaky' speech with deconvolution analysis of electroencephalography recordings. We show that in adults with normal hearing the method quickly yields robust responses whose component waves reflect activity from distinct subcortical structures spanning auditory nerve to rostral brainstem. We further demonstrate the versatility of peaky spe

SUBMITTER: Polonenko MJ 

PROVIDER: S-EPMC7946424 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature