Monocyte-derived dendritic cells link localized secretory IgA deficiency to adaptive immune activation in COPD.

ABSTRACT: Although activation of adaptive immunity is a common pathological feature of chronic obstructive pulmonary disease (COPD), particularly during later stages of the disease, the underlying mechanisms are poorly understood. In small airways of COPD patients, we found that localized disruption of the secretory immunoglobulin A (SIgA)-containing mucosal immunobarrier correlated with lymphocyte accumulation in airway walls and development of tertiary lymphoid structures (TLS) around small airways. In SIgA-deficient mice, we observed bacterial invasion into the airway epithelial barrier with lymphocytic infiltration and TLS formation, which correlated with the progression of COPD-like pathology with advanced age. Depletion of either CD4⁺ or CD8⁺ T lymphocytes reduced the sev

SUBMITTER: Richmond BW 

PROVIDER: S-EPMC7946625 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature