IL-22 receptor signaling in Paneth cells is critical for their maturation, microbiota colonization, Th17-related immune responses, and anti-Salmonella immunity.

ABSTRACT: Interleukin-22 (IL-22) signaling in the intestines is critical for promoting tissue-protective functions. However, since a diverse array of cell types (absorptive and secretory epithelium as well as stem cells) express IL-22Ra1, a receptor for IL-22, it has been difficult to determine what cell type(s) specifically respond to IL-22 to mediate intestinal mucosal host defense. Here, we report that IL-22 signaling in the small intestine is positively correlated with Paneth cell differentiation programs. Our Il22Ra1^fl/fl;Lgr5-EGFP-cre^ERT2-specific knockout mice and, independently, our lineage-tracing findings rule out the involvement of Lgr5⁺ intestinal stem cell (ISC)-dependent IL-22Ra1 signaling in regulating the lineage commitment of epithelial cells, includ

SUBMITTER: Gaudino SJ 

PROVIDER: S-EPMC7946635 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature