Family history of prostate cancer and prostate tumor aggressiveness in black and non-black men;results from an equal access biopsy study.

ABSTRACT:

Purpose

To test for racial differences in associations between family history (FH) of prostate cancer (PC) and prostate cancer aggressiveness in a racially diverse equal access population undergoing prostate biopsy.

Subjects/patients and methods

We prospectively enrolled men undergoing prostate biopsy at the Durham Veterans Administration from 2007 to 2018 and assigned case or control status based on biopsy results. Race and FH of PC were self-reported on questionnaires. Logistic regression was used to test the association between FH and PC diagnosis overall and by tumor aggressiveness [high- (Grade Group 3-5) or low-grade (Grade Group 1-2) vs. no cancer], overall, and stratified by race. Models were adjusted for age and year of consent, race, PSA level, digital rectal exam

SUBMITTER: Jenkins KR 

PROVIDER: S-EPMC7946692 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature