Delivery of eupenifeldin via polymer-coated surgical buttresses prevents local lung cancer recurrence.

ABSTRACT: Lung cancer is the leading cause of cancer deaths worldwide. Unfortunately, high recurrence rates and poor survival remain despite surgical resection and conventional chemotherapy. Local drug delivery systems are a promising intervention for lung cancer treatment with the potential for improved efficacy with reduced systemic toxicity. Here, we describe the development of a chemotherapy-loaded polymer buttress, to be implanted along the surgical margin at the time of tumor resection, for achieving local and prolonged release of a new anticancer agent, eupenifeldin. We prepared five different formulations of buttresses with varying amounts of eupenifeldin, and additional external empty polymer coating layers (or thicknesses) to modulate drug release. The in vitro eupenifeldin release profile

SUBMITTER: Al Subeh ZY 

PROVIDER: S-EPMC7946725 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature