Conserved IFN Signature between Adult and Pediatric Eosinophilic Esophagitis.

ABSTRACT: Eosinophilic esophagitis (EoE) is an allergic inflammatory disease of the esophagus that occurs in both children and adults. Previous studies of affected tissue from pediatric cohorts have identified prominent signatures of eosinophilia and type 2 inflammation. However, the details of the immune response in adults with EoE are still being elucidated. To determine whether EoE in adults shares inflammatory profiles with those observed in children, we performed RNA sequencing of paired human esophageal biopsies and blood samples from adults with EoE or gastroesophageal reflux disease. Unbiased analysis of differentially expressed genes in tissue revealed a strong IFN signature that was significantly enriched in EoE patients as compared with patients with gastroesophageal reflux disease. Both

SUBMITTER: Ruffner MA 

PROVIDER: S-EPMC7946729 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature