Higher medication complexity in persons with HIV is associated with lower tenofovir diphosphate in dried blood spots.

ABSTRACT:

Study objective

To assess the association between tenofovir diphosphate (TFV-DP) in dried blood spots (DBS), a measure of cumulative tenofovir-based antiretroviral (ART) adherence, with medication regimen complexity in persons with human immunodeficiency virus (PWH).

Design

Prospective clinical cohort (up to three visits over 48 weeks).

Setting

Academic-based HIV clinic.

Patients

PWH receiving tenofovir disoproxil fumarate (TDF)-based ART.

Measurements

DBS for TFV-DP were collected at every study visit. Baseline patient-level medication regimen complexity index (pMRCI) scores were calculated and categorized into three sub-scores (disease-specific [ART], non-ART, and over-the-counter [OTC]). The pMRCI scores were evaluated to assess the association with T

SUBMITTER: Saderup AM 

PROVIDER: S-EPMC7946741 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature