Phthalate exposures and one-year change in body mass index across the menopausal transition.

ABSTRACT:

Background

The menopausal transition is a hormonally sensitive period associated with changes in body weight. Phthalates are ubiquitous endocrine disrupting chemicals that could disrupt weight homeostasis, but it is unknown whether this occurs during the menopausal transition.

Objectives

Our objectives were to (1) determine if phthalate exposure in pre- and perimenopausal women was associated with one-year change in body mass index (BMI), and (2) determine if these associations differed across the menopausal transition.

Methods

We addressed our objectives using data from 524 participants enrolled in the Midlife Women's Health Study. We calculated change in BMI from baseline to first follow-up visit approximately one year later. Phthalate exposures were approximated by

SUBMITTER: Haggerty DK 

PROVIDER: S-EPMC7946761 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature