Brain MRI after critical care admission: A longitudinal imaging study.

ABSTRACT:

Purpose

To investigate the association between episodes of critical care hospitalizations and delirium with structural brain changes in older adults.

Materials and methods

We included Mayo Clinic Study of Aging participants ≥60 years old at the time of study enrollment (October 29, 2004, through September 11, 2017) with available brain MRI and 'amyloid' positron emission tomography (PET) scans. We tested the hypothesis that a) intensive care unit (ICU) admission is associated with greater cortical thinning and atrophy in entorhinal cortex, inferior temporal cortex, middle temporal cortex, and fusiform cortex (Alzheimer''s disease-signature regions); b) atrophy in hippocampus and corpus callosum; c) delirium accelerates these changes; and d) ICU admission is not associated wi

SUBMITTER: Sprung J 

PROVIDER: S-EPMC7946765 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature