Early Detection of Checkpoint Inhibitor-Associated Myocarditis Using ⁶⁸Ga-FAPI PET/CT.

ABSTRACT: Objective: Checkpoint inhibitors (ICIs) have gained importance in recent years regarding the treatment of a variety of oncologic diseases. The possibilities of diagnosing cardiac adverse autoimmune effects of ICIs are still limited. We aimed to implement FAPI PET/CT imaging in detecting ICI-associated myocarditis. Methods: In a retrospective study, FAPI PET/CT scans of 26 patients who received ICIs from 01/2017 to 10/2019 were analyzed. We compared tracer enrichment in the heart of patients without any signs of a cardiac disease (n = 23) to three patients with suspected ICI-associated myocarditis. To exclude any significant coronary heart disease, cardiac catherization was performed. All three patients' myocardial biopsies were examined for inflammatory cells. Resul

SUBMITTER: Finke D 

PROVIDER: S-EPMC7946849 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature