Galectin-9 expression correlates with therapeutic effect in rheumatoid arthritis.

ABSTRACT: Galectin-9 (Gal-9) is a multifunctional immunomodulatory factor highly expressed in RA. This study aimed to investigate the expression of Gal-9 and its correlation with disease activity and therapeutic response in RA patients. Active RA patients were enrolled and treated with tacrolimus (TAC) alone or in combination therapy for 12 weeks in a prospective cohort study. Clinical and immunological parameters were recorded at baseline and week 12. We measured Gal-9 expression in different T cell subsets and in plasma. The disease activity of RA patients decreased after treatment. At baseline, the Gal-9 expression percentage was higher in the group with severe disease than in mild or moderate groups. After treatment, the Gal-9 expression in CD3⁺, CD4⁺, CD8⁺ and C

SUBMITTER: Sun J 

PROVIDER: S-EPMC7946964 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature