A Functional Variant rs3093023 in CCR6 Is Associated With IgA Nephropathy by Regulating Th17 Cells in a North Han Chinese Population.

ABSTRACT: C-C chemokine receptor 6 (CCR6) is a susceptibility gene of various immune-related diseases, which was suggested to be shared with immunoglobulin A nephropathy (IgAN). In this study, we aimed to identify the functional variants. First, we analyzed the associations of CCR6 common and rare variants detected by multi-platform chips with IgAN susceptibility using imputation and identified 68 significantly associated common variants located in the regulatory region. Among them, rs3093023 showed both statistical significance (rs3093023-A, odds ratio [OR] = 1.15, P = 2.00 × 10^-2) and the expression quantitative trait loci (eQTL) effect (P = 1.45 × 10^-3). It was independently replicated (rs3093023-A, OR = 1.18, P = 5.56 × 10^-3) an

SUBMITTER: Zhang YM 

PROVIDER: S-EPMC7946973 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature