Quercetin-Conjugated Superparamagnetic Iron Oxide Nanoparticles Protect AlCl₃-Induced Neurotoxicity in a Rat Model of Alzheimer's Disease via Antioxidant Genes, APP Gene, and miRNA-101.

ABSTRACT: Alzheimer's disease (AD) is a neurodegenerative disease with cognitive impairment. Oxidative stress in neurons is considered as a reason for development of AD. Antioxidant agents such as quercetin slow down AD progression, but the usage of this flavonoid has limitations because of its low bioavailability. We hypothesized that quercetin-conjugated superparamagnetic iron oxide nanoparticles (QT-SPIONs) have a better neuroprotective effect on AD than free quercetin and regulates the antioxidant, apoptotic, and APP gene, and miRNA-101. In this study, male Wistar rats were subjected to AlCl₃, AlCl₃ + QT, AlCl₃ + SPION, and AlCl₃ + QT-SPION for 42 consecutive days. Behavioral tests and qPCR were used to evaluate the efficiency of treatments. Results of

SUBMITTER: Amanzadeh Jajin E 

PROVIDER: S-EPMC7947204 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature