Human Atrial Fibrillation Is Not Associated With Remodeling of Ryanodine Receptor Clusters.

ABSTRACT: The release of Ca²⁺ by ryanodine receptor (RyR2) channels is critical for cardiac function. However, abnormal RyR2 activity has been linked to the development of arrhythmias, including increased spontaneous Ca²⁺ release in human atrial fibrillation (AF). Clustering properties of RyR2 have been suggested to alter the activity of the channel, with remodeling of RyR2 clusters identified in pre-clinical models of AF and heart failure. Whether such remodeling occurs in human cardiac disease remains unclear. This study aimed to investigate the nanoscale organization of RyR2 clusters in AF patients - the first known study to examine this potential remodeling in diseased human cardiomyocytes. Right atrial appendage from cardiac surgery patients with paroxysmal or persistent A

SUBMITTER: Munro ML 

PROVIDER: S-EPMC7947344 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature