Delivery of gefitinib with an immunostimulatory nanocarrier improves therapeutic efficacy in lung cancer.

ABSTRACT:

Background

Combining different cancer treatments represents a promising strategy to improve the therapeutic outcome for lung cancer patients with or without druggable gene alterations.

Methods

We previously developed a polyethylene glycol-based (PEG-based) immunostimulatory nanocarrier (PEG_2k-Fmoc-NLG919) which can efficiently co-deliver an indoleamine 2,3-dioxygenase-1 (IDO1) inhibitor and the chemotherapeutic agent, paclitaxel. This method was found to improve cancer therapy by simultaneously performing immuno- and chemo-therapy. However, whether this nanocarrier could deliver targeted drugs to implement targeted therapy together with immunotherapy remains unclear.

Results

Here, we report that the delivery of the classical tyrosine kinase inhibitor (TKI),

SUBMITTER: Diao D 

PROVIDER: S-EPMC7947404 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature