Identifying the prognostic significance of B3GNT3 with PD-L1 expression in lung adenocarcinoma.

ABSTRACT:

Background

As a novel treatment, programmed cell death protein 1 (PD-1) inhibitor appears to be less effective in tumors of lung adenocarcinoma patients with epidermal growth factor receptor (EGFR) mutation. Beta-1,3-N-acetylglucosaminyltransferase 3 (B3GNT3) has reported to be associated with programmed death ligand 1 (PD-L1)/PD-1 interaction. However, the relationship between B3GNT3 and PD-L1 and its prognostic significance in.

Egfr

mutant status are still unknown.

Methods

B3GNT3 was identified through transcriptome sequencing and The Cancer Genome Atlas Lung Adenocarcinoma (TCGA-LUAD) database. Flow cytometry and real-time polymerase chain reaction were performed to investigate the association between B3GNT3, PD-L1, and EGFR. Then, B3GNT3 and PD-L1 ex

SUBMITTER: Leng X 

PROVIDER: S-EPMC7947420 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature