Identification of genes that correlate clear cell renal cell carcinoma and obesity and exhibit potential prognostic value.

ABSTRACT:

Background

Renal cell carcinoma (RCC) is a common urologic malignancy. Although the relationship between clear cell RCC (ccRCC) and obesity has been well-established by several large-scale retrospective studies, the molecular mechanisms and genetic characteristics behind this correlation remains unclear. In the current study, several bioinformatics tools were used to identify the key genes in ccRCC related to obesity.

Methods

Microarray data comparing ccRCC with normal renal tissues in patients with and without obesity were downloaded from the GEO database for screening of differentially expressed genes (DEGs). The DEGs were verified with expression level and survival analysis using several online bioinformatics tools.

Results

In the current study, the differential ex

SUBMITTER: Zhou J 

PROVIDER: S-EPMC7947457 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature