Competing endogenous RNA network analysis reveals pivotal ceRNAs in bladder urothelial carcinoma.

ABSTRACT:

Background

Bladder urothelial cancer (BUC) has become one of the most frequently occurring malignant tumors worldwide and it is of great importance to explore the molecular pathogenesis of bladder cancer. Emerging evidence has demonstrated that dysregulation of noncoding RNAs is critically involved in the tumorigenesis and progression of BUC. Long noncoding RNAs (lncRNAs) can act as microRNA (miRNA) sponges to regulate protein-coding gene expression and therefore form a competing endogenous RNA (ceRNA) network. ceRNA networks have been proven to play vital roles during tumorigenesis and progression. Elements involved in the ceRNA network have also been identified as potential therapeutic targets and prognostic biomarkers in various tumors. Understanding the regulatory mechanisms an

SUBMITTER: Li Y 

PROVIDER: S-EPMC7947459 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature