Characterisation of a clinical isolated Aspergillus lentulus strain using a Galleria mellonella infection model.

ABSTRACT:

Background

In recent years, the number of invasive aspergillus infection cases caused by Aspergillus lentulus (A. lentulus) has gradually increased and this fungus is usually difficult to distinguish from Aspergillus fumigatus in morphology. All of these presents a great challenge to the treatment of invasive fungal infections caused by A. lentulus. The present study aims to discuss the antifungal resistance, virulence and inflammatory factors' changes after the infection of larvae of A. lentulus separated from patients with chronic obstructive pulmonary disease (COPD) to reflect the host immune response.

Methods

A. lentulus isolated from COPD patients was identified by morphology and molecular biology, and its drug sensitivity was d

SUBMITTER: Zhang LJ 

PROVIDER: S-EPMC7947491 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature